FOXO4
FOXO4
$ 340
A senolytic peptide that disrupts the interaction between FOXO4 and p53 proteins in senescent (‘zombie’) cells. Senescent cells accumulate with age, secrete inflammatory signals, and resist normal apoptosis. FOXO4-DRI forces these cells into apoptosis (cell death) while leaving healthy cells intact.
Benefits
✓ Selectively eliminates senescent cells
✓ Reduces senescence-associated secretory phenotype (SASP) / inflammation
✓ Improved fur/hair regrowth in aged animal models
✓ Improved kidney function markers
✓ Increased fitness and endurance in aged animals
✓ Promising anti-aging and rejuvenation tool
✓ Reduces senescence-associated secretory phenotype (SASP) / inflammation
✓ Improved fur/hair regrowth in aged animal models
✓ Improved kidney function markers
✓ Increased fitness and endurance in aged animals
✓ Promising anti-aging and rejuvenation tool
Side Effects
• Flu-like symptoms 1–3 days post-injection (indicates cellular clearance)
• Injection site redness
• Fatigue
• Theoretical oncogenic risk (p53 pathway involvement)
• Long-term human safety data limited
• Injection site redness
• Fatigue
• Theoretical oncogenic risk (p53 pathway involvement)
• Long-term human safety data limited
Half Life
Unknown
Note
FOXO4
$ 340
A senolytic peptide that disrupts the interaction between FOXO4 and p53 proteins in senescent (‘zombie’) cells. Senescent cells accumulate with age, secrete inflammatory signals, and resist normal apoptosis. FOXO4-DRI forces these cells into apoptosis (cell death) while leaving healthy cells intact.
✓ Selectively eliminates senescent cells
✓ Reduces senescence-associated secretory phenotype (SASP) / inflammation
✓ Improved fur/hair regrowth in aged animal models
✓ Improved kidney function markers
✓ Increased fitness and endurance in aged animals
✓ Promising anti-aging and rejuvenation tool
✓ Reduces senescence-associated secretory phenotype (SASP) / inflammation
✓ Improved fur/hair regrowth in aged animal models
✓ Improved kidney function markers
✓ Increased fitness and endurance in aged animals
✓ Promising anti-aging and rejuvenation tool
Unknown